Table of contents

Therapeutics/Prevention

• Randomised controlled trial: LABA/LAMA combinations instead of LABA/ICS combinations may prevent or delay exacerbations of COPD in some patients (15 September, 2016)

  Mario Cazzola, Paola Rogliani
• Systematic review with meta-analysis: Most add-on therapies to metformin have similar effects on HbA1c (27 September, 2016)

  Thomas Karagiannis, Eleni Bekiari
• Systematic review with meta analysis: Existing evidence is insufficient to justify metformin or other agents as first-line therapy for type 2 diabetes (18 October, 2016)

  Rene Rodriguez-Gutierrez, Victor M Montori
• Systematic review with meta analysis: Aspirin reduces cardiovascular events in primary prevention of cardiovascular disease but at a near equivalent risk of increased bleeding (25 October, 2016)

  Michael D Miedema, Salim S Virani
• Systematic review with meta analysis: Uncertainty in evidence synthesis limits clinical applicability of a clinical and cost-effectiveness analysis of induction of labour methods (3 November, 2016)

  Christina Davidson
• Observational study: Compared to conventional CPR for in-hospital cardiac arrest, extracorporeal-CPR is associated with improved survival to hospital discharge and more favourable neurological outcome (1 September, 2016)

  Lindsay Ryerson, Gonzalo Garcia Guerra, Laurance Lequier
• Randomised controlled trial: In individuals at intermediate risk for cardiovascular disease, treatment with rosuvastatin but not candesartan plus hydrochlorothiazide lowers cardiovascular disease event rates (6 October, 2016)

  Michael LeFevre