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QUESTION: Is an increased plasma total homocysteine concentration a risk factor for dementia in the elderly?
Design
Cohort study with a median follow up of 8 years.
Setting
Framingham, Massachusetts, USA.
Participants
1092 elderly participants (mean age 76 y, 61% women) from the Framingham Study cohort who were free from dementia and had plasma total homocysteine levels measured at their 20th biennial examination.
Assessment of risk factors
Baseline data were collected on the plasma total homocysteine level. Analyses were adjusted for baseline age; sex; apolipoprotein E genotype (93% of participants); plasma levels of folate (98% of participants), vitamin B-12 (85% of participants), and vitamin B-6 (92% of participants); educational status; history of stroke; cigarette smoking; alcohol intake; diabetes mellitus; systolic blood pressure; and body mass index.
Main outcome measures
Dementia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, …
Footnotes
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Source of funding: National Institutes of Health.
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For correspondence: Dr P A Wolf, Boston University School of Medicine, Boston, Massachusetts, USA. pawolf{at}bu.edu.
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Abstract and commentary also appear in Evidence-Based Mental Health
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