Footnotes

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• Contributors PI contributed to conception and design of the paper, stewardship of the discussion within the panel of the authors for the production of the safety bundle, critical assessment of the literature about guideline methodology and appraisal, selection of case studies cited; draft of the manuscript. NM, MM and AC made substantial contributions to the acquisition, analysis and interpretation of current methodology of guidelines appraisal; revision of the manuscript for important intellectual content; final approval of the version published. JD, GC and GMP made substantial contributions to the analysis, interpretation of relevant literature considered and of the case studies to be tested with the safety bundle; revision of the manuscript for important intellectual content; final approval of the version published. All of the authors agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

• Competing interests None declared.

• Provenance and peer review Not commissioned; internally peer reviewed.